P4 medicine (Predictive, Preventive, Personalized, and Participatory) offers a comprehensive approach to personalized healthcare, emphasizing both the transition from disease to wellness and the importance of preventive care. In this perspective, we propose a…
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Real-time prediction of short-term mortality risk in the intensive care unit (ICU) is often hampered by missing medical data. To address this, we developed RealMIP, an end-to-end framework leveraging generative model for the dynamic…
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Synthetic tabular data generation (SDG) is increasingly important in healthcare research and innovation while preserving patients’ privacy. However, ethical concerns remain, primarily over residual privacy vulnerability and insufficient oversight. This review analyzes the only…
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Sjögren’s disease (SjD) is a common systemic autoimmune disease that remains difficult to diagnose early due to non-specific symptoms and lack of definitive biomarkers. This multicentre retrospective cohort study analysed data from 34,958 patients…
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Vision-language models (VLMs) show promise for answering clinically relevant questions, but their robustness to medical image artefacts remains unclear. We evaluated VLMs’ robustness through their performance on images with and without weak artefacts across…
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As an effective strategy for preventing influenza, vaccination uptake remains suboptimal. This cluster randomised trial evaluated digital messaging nudges on influenza vaccination among children aged 6-35 months and their parents in China. During 2024-25…
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Alzheimer’s Disease (AD), the most common neurodegenerative disease, is underdiagnosed and more prominent in underrepresented groups. We performed semi-supervised positive unlabeled learning (SSPUL) coupled with racial bias mitigation for equitable prediction of undiagnosed AD…
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Accurate detection of lung cancer from Computed Tomography (CT) scans is vital for improving patient survival but remains challenging for deep learning models, which struggle with scale variations of pulmonary nodules and the complex…
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Effective risk stratification is essential in clinical practice, enabling better resource allocation and improved patient outcomes. Although machine learning models have been widely used for risk prediction and stratification in electronic health record (EHR)…
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Lung cancer remains the top cause of cancer death, demanding consistent decisions. This clinically oriented review synthesizes computer-aided diagnosis across classical imaging, machine learning, and deep learning, emphasizing bedside-proven advances: multimodal CT/PET–clinical fusion; small-data…
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