Rapid advances in large language models (LLMs) are transforming the role of students and principal investigators (PIs) in biomedical research. This perspective examines how LLMs can reshape the laboratory model as de facto “Co-PIs”…
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Accurate and comprehensive interpretation of pulmonary embolism (PE) from Computed Tomography Pulmonary Angiography (CTPA) scans remains a clinical challenge due to the limited specificity and structure of existing AI tools. We propose an agent-based…
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We introduce a framework to adapt large language models for medicine: (1) Modeling: breaking down medical workflows into manageable steps; (2) Optimization: optimizing model performance via advanced adaptations; and (3) System engineering: developing agent…
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Cognitive bias accounts for a significant portion of preventable errors in healthcare, contributing to significant patient morbidity and mortality each year. As large language models (LLMs) are introduced into healthcare and clinical decision-making, these…
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Rare gynecological tumors (RGTs) present major clinical challenges due to their low incidence and heterogeneity. The lack of clear guidelines leads to suboptimal management and poor prognosis. Molecular tumor boards accelerate access to effective…
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Generative AI has the potential to transform patient care, but it can also wreak havoc if left unattended.
By Paul Cerrato, MA, senior research analyst and communications specialist and John Halamka, M.D., Diercks President, Mayo…
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Subspecialty knowledge barriers have limited the adoption of large language models (LLMs) in oncology. We introduce Woollie, an open-source, oncology-specific LLM trained on real-world data from Memorial Sloan Kettering Cancer Center (MSK) across lung,…
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Large language models (LLMs) demonstrate significant potential in healthcare applications, but clinical deployment is limited by privacy concerns and insufficient medical domain training. This study investigated whether retrieval-augmented generation (RAG) can improve locally deployable…
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We reviewed 1016 FDA authorizations of AI/ML-enabled medical devices to develop a taxonomy capturing key variations in clinical and AI-related features. Quantitative image analysis remains the most common application, but its relative proportion has…
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Ambient digital scribing (ADS) tools alleviate clinician documentation burden, reducing burnout and enhancing efficiency. As AI-driven ADS tools integrate into clinical workflows, robust governance is essential for ethical and secure deployment. This study proposes…
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