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Tag: Explainable AI

Explainable AI-driven precision clinical trial enrichment: demonstration of the NetraAI platform with a phase II depression trial

Explainable AI-driven precision clinical trial enrichment: demonstration of the NetraAI platform with a phase II depression trial

December 9, 2025December 9, 2025npj Digital Medicine

Clinical trial failures are frequently driven by patient heterogeneity and limited sample sizes that obscure treatment effects by diluting statistical power. We introduce NetraAI, a novel explainable artificial intelligence (AI) platform that integrates dynamical-systems…

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The cost of explainability in artificial intelligence-enhanced electrocardiogram models

The cost of explainability in artificial intelligence-enhanced electrocardiogram models

December 5, 2025December 6, 2025npj Digital Medicine

Artificial intelligence-enhanced electrocardiogram (AI-ECG) models have shown outstanding performance in diagnostic and prognostic tasks, yet their black-box nature hampers clinical adoption. Meanwhile, a growing demand for explainable AI in medicine underscores the need for…

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A systematic review of explainable artificial intelligence methods for speech-based cognitive decline detection

A systematic review of explainable artificial intelligence methods for speech-based cognitive decline detection

November 26, 2025November 26, 2025npj Digital Medicine

Artificial intelligence models analyzing speech show remarkable promise for identifying cognitive decline, achieving performance comparable to clinical assessments. However, their “black box” nature poses significant barriers to clinical adoption, as healthcare professionals require transparent…

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The explainable AI dilemma under knowledge imbalance in specialist AI for glaucoma referrals in primary care

The explainable AI dilemma under knowledge imbalance in specialist AI for glaucoma referrals in primary care

November 21, 2025November 21, 2025npj Digital Medicine

Primary eye care providers refer glaucoma patients using their clinical experience and context. Specialized Artificial Intelligence (AI) excels in referrals trained on clinical data but relies on assumptions that may not hold in practice….

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Unlocking the potential: multimodal AI in biotechnology and digital medicine—economic impact and ethical challenges

Unlocking the potential: multimodal AI in biotechnology and digital medicine—economic impact and ethical challenges

October 20, 2025October 20, 2025npj Digital Medicine

Artificial Intelligence (AI) is revolutionizing biotechnology by accelerating advancements in drug discovery, genomics, medical imaging, and personalized medicine, thereby enhancing efficiency and reducing healthcare costs. This review emphasizes the transformative potential of multimodal AI—systems…

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Comparison of SHAP and clinician friendly explanations reveals effects on clinical decision behaviour

Comparison of SHAP and clinician friendly explanations reveals effects on clinical decision behaviour

September 26, 2025September 26, 2025npj Digital Medicine

Clinical decision-making substantially impacts patients’ lives and their quality of life. However, the black-box nature of AI-powered clinical decision support systems (CDSSs) complicates the interpretation of how decisions are derived. Explainable AI (XAI) improves…

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Liquid white box model as an explainable AI for surgery

Liquid white box model as an explainable AI for surgery

June 20, 2025June 20, 2025npj Digital Medicine

Understanding surgical data in real-time will lead to improved feedback, learning, and performance for surgeons. This is important as data-driven systems offer safer, more standardized surgery, and faster training times. Artificial intelligence shows great…

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Dynamic mortality prediction in critically Ill children during interhospital transports to PICUs using explainable AI

Dynamic mortality prediction in critically Ill children during interhospital transports to PICUs using explainable AI

February 17, 2025February 18, 2025npj Digital Medicine

Critically ill children who require inter-hospital transfers to paediatric intensive care units are sicker than other admissions and have higher mortality rates. Current transport practice primarily relies on early clinical assessments within the initial…

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Explainable AI associates ECG aging effects with increased cardiovascular risk in a longitudinal population study

Explainable AI associates ECG aging effects with increased cardiovascular risk in a longitudinal population study

January 13, 2025January 13, 2025npj Digital Medicine

Aging affects the 12-lead electrocardiogram (ECG) and correlates with cardiovascular disease (CVD). AI-ECG models estimate aging effects as a novel biomarker but have only been evaluated on single ECGs—without utilizing longitudinal data. We validated…

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Hong Kong university to test four genAI models in hospitals

Hong Kong university to test four genAI models in hospitals

November 11, 2024November 11, 2024Healthcare IT news

The Hong Kong University of Science and Technology has recently announced its development of four large language models for healthcare.WHAT IT’S ABOUT
Developed out of HKUST SuperPOD, the university’s AI supercomputing facility, the LLM-based tools…

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The vaccine rollout process is a classic case study for successful projects requiring "people, process and technology." In this equation, the technology infrastructure of an electronic health record and network connectivity seem to be sufficient at most health systems and communities to support the cause. As a result, the most crucial elements to enable success is the project leadership and teamwork amongst all segments of the healthcare delivery system (people and process).

Michael Restuccia

Recent Posts

  • Texas AG sues Epic Systems

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    December 13, 2025December 13, 2025Comments Off on Texas AG sues Epic Systems
  • HIMSSCast: Should GPT-5 be HIPAA compliant, FDA regulated?

    HIMSSCast: Should GPT-5 be HIPAA compliant, FDA regulated?

    December 13, 2025December 13, 2025Comments Off on HIMSSCast: Should GPT-5 be HIPAA compliant, FDA regulated?
  • HIMSSCast: New book offers first-person look back on challenging early chapter for healthcare AI

    HIMSSCast: New book offers first-person look back on challenging early chapter for healthcare AI

    December 13, 2025December 13, 2025Comments Off on HIMSSCast: New book offers first-person look back on challenging early chapter for healthcare AI
  • Healthcare AI implementation needs trust, training and teamwork

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    December 12, 2025December 13, 2025Comments Off on Healthcare AI implementation needs trust, training and teamwork
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    December 12, 2025December 13, 2025Comments Off on Healthcare leaders reveal 2025’s biggest surprises, part one
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