The demand for demographically and geographically diverse, high-quality, fit-for-purpose real-world data has been increasing to support regulatory and other healthcare decision making. Accessing and sharing healthcare data across sites, regions, and countries while ensuring…
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The efficacy of immunotherapy in bladder cancer (BCa) is highly influenced by tumor heterogeneity, underscoring the urgent need for mechanistic insights and precise molecular subtyping. Adenosine-to-inosine RNA editing (AIRE), a critical post-transcriptional mechanism driving…
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Digital mental health interventions (DMHIs) are playing an increasingly important role in supporting mental healthcare. Despite their widespread adoption during and after the COVID-19 pandemic, there has been a lack of review focused on…
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Sleep disturbances are an underrecognized factor associated with reduced workplace productivity (“presenteeism”). Previous studies have largely relied on self-reported sleep data, limiting their scalability and accuracy. We investigated associations between smartphone-based sleep metrics and…
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Digital health tools such as remote patient monitoring (RPM) and digital health coaching (DHC) offer promising strategies for type 2 diabetes (T2D) management, yet little is known about how underserved Black adults experience these…
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Congenital and acquired heart disease affects approximately 1% of children worldwide, and right ventricular (RV) dysfunction is a common and complex manifestation in conditions such as congenital heart disease, pulmonary hypertension, and prematurity. Accurate…
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Clinical trial failures are frequently driven by patient heterogeneity and limited sample sizes that obscure treatment effects by diluting statistical power. We introduce NetraAI, a novel explainable artificial intelligence (AI) platform that integrates dynamical-systems…
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Large language models (LLMs) are increasingly used for mental health interactions, often mimicking therapeutic behaviour without regulatory oversight. Documented harms, including suicides, highlight the urgent need for stronger safeguards. This manuscript argues that LLMs…
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Digital health strategies are increasingly being adopted in Africa, but their consistency with best practice planning is poorly documented. 54 countries were screened; 48 had a plan in the Global Digital Health Monitor, and…
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The clinical application of the frailty phenotype and frailty index still has some limitations, and whether the classification of frailty based on metabolites is beneficial to the management of the frailty population remains unclear….
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