The use of synthetic data to augment real-world data in healthcare can ensure AI models perform more accurately, and fairly across subgroups. By examining a parallel case study of NHS England’s care.data platform, this…
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Closed-loop (CL) neurotechnology, which dynamically adapts to patients’ neural states, offers new opportunities for treating neurological and psychiatric disorders. However, its real-time feedback mechanisms raise critical ethical challenges. This scoping review assesses whether and…
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Clinical evidence synthesis largely relies on systematic reviews (SR) of clinical studies from medical literature. Here, we propose a generative artificial intelligence (AI) pipeline named TrialMind to streamline study search, study screening, and data…
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The current standard-of-care (SOC) practice for defining the clinical target volume (CTV) for radiation therapy (RT) in patients with glioblastoma still employs an isotropic 1–2 cm expansion of the T2-hyperintensity lesion, without considering the heterogeneous…
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Despite widespread interest in integrating mobile health apps into primary care to prevent and manage physical inactivity-related health conditions, the effectiveness of these apps remains unclear. We quantified the effects of Active 10 (a…
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We developed a rapid scanning optical microscope, termed “BlurryScope”, that leverages continuous image acquisition and deep learning to provide a cost-effective and compact solution for automated inspection and analysis of tissue sections. This device…
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Approximately 20% of diabetic foot ulcers (DFUs) patients require lower extremity amputation, and postoperative reulceration and reamputation remains common. To clarify the biomechanical consequences and reulceration risk of different ray amputations (RAs), we built…
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There is growing recognition of the moral and legal authority of Indigenous Peoples to regulate research and other matters that involve their communities under the principle of Indigenous Data Sovereignty (IDS). This systematic review…
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Blepharospasm is a focal dystonia characterized by involuntary eyelid contractions that impair vision and social function. The subtle clinical signs of blepharospasm make early and accurate diagnosis difficult, delaying timely intervention. In this study,…
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This study harnesses machine learning to dissect the complex socioeconomic determinants of depression risk among older adults across five international cohorts (HRS, ELSA, SHARE, CHARLS, MHAS). Evaluating six predictive algorithms, XGBoost demonstrated superior performance…
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