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Diverging trajectories of trust in healthcare and on-line information seeking: what’s next with LLMs

Diverging trajectories of trust in healthcare and on-line information seeking: what’s next with LLMs

February 1, 2026February 1, 2026
Weekly Roundup – January 31, 2026

Weekly Roundup – January 31, 2026

January 31, 2026February 1, 2026
Embedding clinical intelligence to help close care gaps

Embedding clinical intelligence to help close care gaps

January 31, 2026January 31, 2026
Impact of Mobilization Facilitated by Wearable Device Enhanced Patient Monitoring/Electrophysiology Pod–Based Feedback on Postoperative Complications Following Colorectal Cancer Surgery: Randomized Controlled Trial

Impact of Mobilization Facilitated by Wearable Device Enhanced Patient Monitoring/Electrophysiology Pod–Based Feedback on Postoperative Complications Following Colorectal Cancer Surgery: Randomized Controlled Trial

January 31, 2026January 31, 2026
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Author: npj Digital Medicine

How generative AI voice agents will transform medicine

How generative AI voice agents will transform medicine

June 12, 2025June 12, 2025npj Digital Medicine

Generative AI voice agents—conversational systems powered by large language models that can understand and produce natural speech in real time—are poised to transform how health systems engage with patients. While technical and implementation challenges…

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High-resolution lifestyle profiling and metabolic subphenotypes of type 2 diabetes

High-resolution lifestyle profiling and metabolic subphenotypes of type 2 diabetes

June 11, 2025June 11, 2025npj Digital Medicine

Distinct metabolic susceptibilities (beta-cell dysfunction, insulin resistance (IR), and impaired incretin response) underlie type 2 diabetes (T2D). However, their relationships with habitual lifestyle behaviors are underexplored. This study integrated high-resolution lifestyle data from wearable…

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Embodied artificial intelligence in ophthalmology

Embodied artificial intelligence in ophthalmology

June 11, 2025June 11, 2025npj Digital Medicine

Embodied artificial intelligence (EAI) integrates perception, memory, reasoning and action through physical interaction, enabling multimodal dynamic learning and real-time feedback. In ophthalmology, EAI supports data-driven decision-making, improving the precision and personalization of diagnosis, surgery,…

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Evaluating sepsis watch generalizability through multisite external validation of a sepsis machine learning model

Evaluating sepsis watch generalizability through multisite external validation of a sepsis machine learning model

June 11, 2025June 11, 2025npj Digital Medicine

Sepsis accounts for a substantial portion of global deaths and healthcare costs. The objective of this reproducibility study is to validate Duke Health’s Sepsis Watch ML model, in a new community healthcare setting and…

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Real-time digital intervention on oral pre-exposure prophylaxis adherence among MSM: randomized controlled trial

Real-time digital intervention on oral pre-exposure prophylaxis adherence among MSM: randomized controlled trial

June 11, 2025June 11, 2025npj Digital Medicine

Oral pre-exposure prophylaxis (PrEP) effectively prevents HIV among men who have sex with men, but its adherence faces significant hindrances. We evaluated the effectiveness of real-time digital intervention in promoting oral PrEP adherence through…

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Economic analysis of an AI-enabled ECG alert system: impact on mortality outcomes from a pragmatic randomized trial

Economic analysis of an AI-enabled ECG alert system: impact on mortality outcomes from a pragmatic randomized trial

June 11, 2025June 11, 2025npj Digital Medicine

Findings from a previous study (ClinicalTrials.gov: NCT05118035) demonstrated that an AI-enabled electrocardiogram (AI-ECG), combining AI reports and physician alerts, effectively identified hospitalized patients at high risk of mortality and reduced all-cause mortality. This study…

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Development and validation of an interpretable risk prediction model for the early classification of thalassemia

Development and validation of an interpretable risk prediction model for the early classification of thalassemia

June 10, 2025June 10, 2025npj Digital Medicine

Thalassemia is an inherited blood disorder. Current diagnostic methods mainly rely on sophisticated equipment and specifically trained technicians. This study aims to identify and genotype thalassemia by applying machine learning (ML) algorithms to routine…

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A cross population study of retinal aging biomarkers with longitudinal pre-training and label distribution learning

A cross population study of retinal aging biomarkers with longitudinal pre-training and label distribution learning

June 10, 2025June 10, 2025npj Digital Medicine

Retinal age has emerged as a promising biomarker of aging, offering a non-invasive and accessible assessment tool. We developed a deep learning model to estimate retinal age with enhanced accuracy, leveraging retinal images from…

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Empirical evaluation of artificial intelligence distillation techniques for ascertaining cancer outcomes from electronic health records

Empirical evaluation of artificial intelligence distillation techniques for ascertaining cancer outcomes from electronic health records

June 10, 2025June 11, 2025npj Digital Medicine

Phenotypic information for cancer research is embedded in unstructured electronic health records (EHR), requiring effort to extract. Deep learning models can automate this but face scalability issues due to privacy concerns. We evaluated techniques…

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Evaluating evidence-based health information from generative AI using a cross-sectional study with laypeople seeking screening information

Evaluating evidence-based health information from generative AI using a cross-sectional study with laypeople seeking screening information

June 9, 2025June 10, 2025npj Digital Medicine

Large language models (LLMs) are used to seek health information. Guidelines for evidence-based health communication require the presentation of the best available evidence to support informed decision-making. We investigate the prompt-dependent guideline compliance of…

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Transformation implies an order of magnitude improvement in performance, as opposed to incremental improvement. Digital implies the convergence of technologies in which the total is greater than the sum of the parts. Thus, digital transformation unlocks breakthrough or innovative business performance through the synergistic use of technology. Said another way, digital transformation is what turns the lead into gold.

Andy Lehman

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